Technology Process of (2R,3S,4R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol
There total 8 articles about (2R,3S,4R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(cyclopentadienyl)titanium dichloride; zinc(II) chloride; zinc;
In
tetrahydrofuran;
at -20 - 20 ℃;
for 13h;
Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(02)00241-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1: mCPBA
2: Zn; ZnCl2; cp2TiCl2 / tetrahydrofuran / 13 h / -20 - 20 °C
With
bis(cyclopentadienyl)titanium dichloride; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; zinc;
In
tetrahydrofuran;
1: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1016/S0040-4039(02)00241-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: LDA / tetrahydrofuran
1.2: tetrahydrofuran
2.1: LAH / diethyl ether
3.1: Et3N; DMAP / CH2Cl2
4.1: 52 percent / (+)-diisopropyl L-tartrate; Ti(iPrO)4; TBHP / CH2Cl2; toluene / 1 h / -20 °C
5.1: mCPBA / CH2Cl2
6.1: ZnCl2; cp2TiCl2; 1,4-cyclohexadiene
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; bis(cyclopentadienyl)titanium dichloride; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; cyclohexa-1,4-diene; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
1.1: Metallation / 1.2: Addition / 2.1: Reduction / 3.1: silylation / 4.1: Epoxidation / 5.1: Epoxidation / 6.1: Ring cleavage;
