5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

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Chemical Name:5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole
CAS No.:864367-81-7
Molecular Formula:C₄₀H₆₈N₄O₁₀S
Molecular Weight:797.067
Hs Code.:

5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

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Chemical Property of 5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

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Technology Process of 5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

There total 11 articles about 5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864367-79-3
5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butylsulfanyl)-1-phenyl-1H-tetrazole

: 864367-81-7
5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/b504937g

Reference yield:

: (1S,4R,5S,7S)-5-Decyl-7-vinyl-6,8-dioxa-bicyclo[3.2.1]octan-4-ol

: 864367-81-7
5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / BF₃*Et₂O; Et₃SiH / CH₂Cl₂ / 3.5 h / -40 °C

2: 61 mg / PhCH=Ru{[(Mes)NCH₂CH₂N(Mes)]CH}(PCy₃)Cl₂ / CH₂Cl₂ / 36 h / 20 °C

3: 99 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

4: 79 percent / K₂CO₃ / methanol / 18 h / 20 °C

5: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 24 h / 20 °C

6: 93 percent / NaOMe / methanol / 12 h / Heating

7: 97 percent / PPh₃; DIAD / tetrahydrofuran / 0.5 h / 20 °C

8: 39.9 mg / m-chloroperoxybenzoic acid; NaHCO₃ / CH₂Cl₂ / 12 h / 20 °C

With triethylsilane; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1039/b504937g

Reference yield:

: 608532-15-6
2,2-Dimethyl-propionic acid 4-[(2R,5S)-5-((S)-1-acetoxy-allyl)-tetrahydro-furan-2-yl]-butyl ester

: 864367-81-7
5-(4-{(2R,5S)-5-[(1S,4S)-4-((2S,5R,6S)-6-Decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-1,4-bis-methoxymethoxy-butyl]-tetrahydro-furan-2-yl}-butane-1-sulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 7 steps

1: 61 mg / PhCH=Ru{[(Mes)NCH₂CH₂N(Mes)]CH}(PCy₃)Cl₂ / CH₂Cl₂ / 36 h / 20 °C

2: 99 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

3: 79 percent / K₂CO₃ / methanol / 18 h / 20 °C

4: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 24 h / 20 °C

5: 93 percent / NaOMe / methanol / 12 h / Heating

6: 97 percent / PPh₃; DIAD / tetrahydrofuran / 0.5 h / 20 °C

7: 39.9 mg / m-chloroperoxybenzoic acid; NaHCO₃ / CH₂Cl₂ / 12 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; sodium methylate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1039/b504937g