(1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester

Base Information

• Chemical Name: (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester
• CAS No.: 265096-99-9
• Molecular Formula: C₄₄H₄₆O₁₄
• Molecular Weight: 798.841
• Mol file: 265096-99-9.mol

Synonyms:

Chemical Property of (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester

There total 2 articles about (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + (1S,4aS,7aS)-1-((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester (265096-97-7) → (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester (265096-99-9)

Guidance literature:

With pyridine;

DOI:10.1248/cpb.48.415

Reference yield:

trityl chloride (76-83-5) → (1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester (265096-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / pyridine / 20 °C

2: 16.0 mg / pyridine

With pyridine; 1: tritylation / 2: Acetylation;

DOI:10.1248/cpb.48.415

Reference yield:

(1S,4aS,7aS)-1-((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester (265096-99-9) → 10-O-benzoyladoxoside tetraacetate

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / 80 percent aq. AcOH / 0.67 h / 80 °C

2: 23 percent / H₂ / PtP₂ / ethanol / 20 °C

3: 100 percent / pyridine / 20 °C

With pyridine; hydrogen; acetic acid; PtP₂; In ethanol; 1: detritylation / 2: Catalytic hydrogenation / 3: benzoylation;

DOI:10.1248/cpb.48.415

upstream raw materials:

acetic anhydride

(1S,4aS,7aS)-1-((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-trityloxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester

trityl chloride