(3beta,5alpha)-3,17-dihydroxypregnane-11,20-dione

Base Information

• Chemical Name: (3beta,5alpha)-3,17-dihydroxypregnane-11,20-dione
• CAS No.: 570-38-7
• Molecular Formula: C₂₁H₃₂O₄
• Molecular Weight: 348.483
• Mol file: 570-38-7.mol

Synonyms:11,20-Allopregnanedione,3b,17a-dihydroxy- (5CI); 5a-Pregnane-11,20-dione, 3b,17-dihydroxy- (8CI); 3b,17-Dihydroxy-5a-pregnane-11,20-dione; 3b,17a-Dihydroxy-5a-pregnane-11,20-dione;NSC 82864

Chemical Property of (3beta,5alpha)-3,17-dihydroxypregnane-11,20-dione

Chemical Property:

• Vapor Pressure: 3.06E-12mmHg at 25°C
• Boiling Point: 503.4°C at 760 mmHg
• Flash Point: 272.3°C
• Density: 1.184g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3beta,5alpha)-3,17-dihydroxypregnane-11,20-dione

There total 8 articles about (3beta,5alpha)-3,17-dihydroxypregnane-11,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

UC1017 (565-99-1,566-00-7,16472-72-3,23930-19-0,82597-79-3,102849-04-7,600-59-9) + acetic anhydride (108-24-7) → (3β,5α)-3,17-dihydroxypregnane-11,20-dione (570-39-8,570-40-1,641-78-1,56193-64-7,570-38-7)

Guidance literature:

With toluene-4-sulfonic acid; nachfolgende Umsetzung mit Peroxybenzoesaeure und mit wss.-aethanol.KOH;

DOI:10.1021/ja01610a038

Reference yield:

3β-acetoxy-17-hydroxy-5α-pregnane-11,20-dione (7253-11-4) → (3β,5α)-3,17-dihydroxypregnane-11,20-dione (570-39-8,570-40-1,641-78-1,56193-64-7,570-38-7)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01142a022

Reference yield:

3β-acetoxy-5α-pregn-16-ene-11,20-dione (2724-68-7) → (3β,5α)-3,17-dihydroxypregnane-11,20-dione (570-39-8,570-40-1,641-78-1,56193-64-7,570-38-7)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; aqueous hydrogen peroxide; aq. NaOH solution / Erwaermen des Reaktionsprodukts mit Acetanhydrid und Pyridin

2: HBr; acetic acid / nachfolgendes Behandeln mit Raney-Nickel in Aethanol

3: methanol.NaOH

With methanol; sodium hydroxide; hydrogen bromide; dihydrogen peroxide; acetic acid;

DOI:10.1021/ja01142a022

upstream raw materials:

17-hydroxy-5α-pregnane-3,11,20-trione

3β-acetoxy-17-hydroxy-5α-pregnane-11,20-dione

UC₁₀₁₇

acetic anhydride

Downstream raw materials:

21-acetoxy-17-hydroxy-5α-pregnane-3,11,20-trione

21-bromo-3β,17-dihydroxy-5α-pregnane-11,20-dione

17-hydroxy-5α-pregnane-3,11,20-trione