1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one

Base Information

• Chemical Name: 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one
• CAS No.: 1452406-14-2
• Molecular Formula: C₁₃H₁₂F₆O
• Molecular Weight: 298.228
• Mol file: 1452406-14-2.mol

Synonyms:

Chemical Property of 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one

There total 4 articles about 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E,4E)-ethyl 5-(4'-fluorophenyl)penta-2,4-dienoate (1357591-15-1) → 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one (1452406-14-2)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h

2: sodium hydroxide / ethanol / 12 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

4: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmc.2013.07.010

Reference yield:

ethyl 5-(4-fluorophenyl)pentanoate → 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one (1452406-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 12 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

3: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmc.2013.07.010

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 1,1,1,2,2-pentafluoro-7-(4-fluorophenyl)heptan-3-one (1452406-14-2)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hydroxide / tetrahydrofuran / 24 h / Molecular sieve; Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 12 h

3: sodium hydroxide / ethanol / 12 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 1: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.bmc.2013.07.010

upstream raw materials:

(2E,4E)-ethyl 5-(4'-fluorophenyl)penta-2,4-dienoate

4-fluorobenzaldehyde

5-(4-fluorophenyl)-pentanoic acid