(3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Base Information

Chemical Name:(3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate
CAS No.:1620523-79-6
Molecular Formula:C₄H₄O₄*C₃₀H₃₉FN₄O₂
Molecular Weight:622.737
Hs Code.:

Synonyms:

Suppliers and Price of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

There total 11 articles about (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620523-77-4
tert-butyl (3S,5S)-3-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1620523-79-6
(3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Guidance literature:: tert-butyl (3S,5S)-3-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.666667h;

(2E)-but-2-enedioic acid; In methanol; dichloromethane; at 20 ℃; for 0.0833333h;
DOI:10.3987/COM-14-12988

Reference yield:

: 1620523-75-2
1-tert-butyl 3-methyl (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]piperidine-1,3-dicarboxylate

: 1620523-79-6
(3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 0 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3.2: 0.08 h / 20 °C

With lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-12988

Reference yield:

: 1620523-71-8
1-tert-butyl 3-methyl (3S,5R)-5-(2,2-dimethylbut-3-enoyl)piperidine-1,3-dicarboxylate

: 1620523-79-6
(3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ozone / dichloromethane / 3 h / -78 °C / Inert atmosphere

1.2: 18 h / -78 - 4 °C

2.1: acetic acid / toluene / 1 h / 80 °C / Cooling with ice

2.2: 1.5 h / 20 °C

3.1: dichloromethane; N,N-dimethyl acetamide / 0 - 20 °C

4.1: 18-crown-6 ether / tetrahydrofuran; toluene / 0.5 h / -78 °C

4.2: -78 - -20 °C

5.1: lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 0 °C

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Cooling with ice

7.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

7.2: 0.08 h / 20 °C

With 18-crown-6 ether; lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-14-12988