N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide

Base Information

• Chemical Name: N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide
• CAS No.: 1973485-26-5
• Molecular Formula: C₁₁H₁₀BrN₃O
• Molecular Weight: 280.124
• Mol file: 1973485-26-5.mol

Synonyms:

Chemical Property of N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-(5-Bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide

There total 3 articles about N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-bromoimidazo[1,2-a]pyridine-2-amine (1350738-82-7) + cyclopropanecarboxylic acid chloride (4023-34-1) → N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide (1973485-26-5)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; for 8h;

Reference yield:

5-bromoimidazo[1,2-a]pyridin-2-ylaminocarboxylic acid tert-butyl ester (1935349-92-0) → N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide (1973485-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Cooling with ice

2: triethylamine / acetonitrile / 24 h / 20 °C / Cooling with ice

With triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

5-bromoimidazo[1,2-a]pyridine-2-carboxylic acid (1026201-52-4) → N-(5-bromoimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide (1973485-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / Cooling with ice; Reflux

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Cooling with ice

3: triethylamine / acetonitrile / 24 h / 20 °C / Cooling with ice

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

5-bromoimidazo[1,2-a]pyridine-2-amine

cyclopropanecarboxylic acid chloride

5-bromoimidazo[1,2-a]pyridin-2-ylaminocarboxylic acid tert-butyl ester

5-bromoimidazo[1,2-a]pyridine-2-carboxylic acid