[⁽¹⁸⁾F]-Raltegravir

Base Information

• Chemical Name: [⁽¹⁸⁾F]-Raltegravir
• CAS No.: 1236352-56-9
• Molecular Formula: C₂₀H₂₁FN₆O₅
• Molecular Weight: 443.424
• Mol file: 1236352-56-9.mol

Synonyms:

Chemical Property of [⁽¹⁸⁾F]-Raltegravir

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [⁽¹⁸⁾F]-Raltegravir

There total 3 articles about [⁽¹⁸⁾F]-Raltegravir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[18F]fluorobenzonitrile (81755-10-4) → [(18)F]-Raltegravir (1236352-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran; dimethyl sulfoxide / 20 - 80 °C / Microwave irradiation; Inert atmosphere

2: tetrahydrofuran; dimethyl sulfoxide / 0.17 h / 80 °C / Microwave irradiation

With dimethylsulfide borane complex; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/jlcr.1778

Reference yield:

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate → [(18)F]-Raltegravir (1236352-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: K[18F]F-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane complex / dimethyl sulfoxide / 0.05 h / 120 °C / Microwave irradiation

2: dimethylsulfide borane complex / tetrahydrofuran; dimethyl sulfoxide / 20 - 80 °C / Microwave irradiation; Inert atmosphere

3: tetrahydrofuran; dimethyl sulfoxide / 0.17 h / 80 °C / Microwave irradiation

With K[18F]F-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane complex; dimethylsulfide borane complex; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/jlcr.1778

Reference yield:

C14H17N5O6 (1236352-55-8) + 4-(([18F]-fluoro)phenyl)methanamine (131865-54-8) → [(18)F]-Raltegravir (1236352-56-9)

Guidance literature:

In tetrahydrofuran; dimethyl sulfoxide; at 80 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1002/jlcr.1778

upstream raw materials:

C₁₄H₁₇N₅O₆

4-(([¹⁸F]-fluoro)phenyl)methanamine

4-[18F]fluorobenzonitrile