C₅₀H₆₆O₂

Base Information

• Chemical Name: C₅₀H₆₆O₂
• CAS No.: 1370028-12-8
• Molecular Formula: C₅₀H₆₆O₂
• Molecular Weight: 699.073
• Mol file: 1370028-12-8.mol

Synonyms:

Chemical Property of C₅₀H₆₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₆₆O₂

There total 16 articles about C₅₀H₆₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

diiodomethane (75-11-6) + C49H64O3 (1370028-11-7) → C50H66O2 (1370028-12-8)

Guidance literature:

diiodomethane; C₄₉H₆₄O₃; With titanium tetrachloride; zinc; In tetrahydrofuran; at 0 - 20 ℃; for 96h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1248/cpb.60.137

Reference yield:

C33H36O3 → C50H66O2 (1370028-12-8)

Guidance literature:

Multi-step reaction with 15 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: toluene / 4.5 h / 120 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

4.1: Crabtree's catalyst; hydrogen / dichloromethane / 48 h / 20 °C / Inert atmosphere

5.1: trimethylaluminum / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 1 h / 0 °C / Inert atmosphere

6.1: tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / 0.67 h / -78 °C / Inert atmosphere

6.2: 1.5 h / Inert atmosphere

7.1: zinc(II) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / diethyl ether / 0.25 h / 0 °C / Inert atmosphere

9.1: sodium hydride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

10.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C / Inert atmosphere

10.2: 0.08 h / 0 °C / Inert atmosphere

11.1: 0.5 h / 0 °C / Inert atmosphere

12.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / 90 °C / Inert atmosphere

13.1: bromocatecholborane / dichloromethane / 1 h / -78 °C / Inert atmosphere

14.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 6 h / 20 °C / Molecular sieve; Inert atmosphere

15.1: titanium tetrachloride; zinc / tetrahydrofuran / 96 h / 0 - 20 °C / Inert atmosphere

15.2: 0.33 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; Crabtree's catalyst; 2,2'-azobis(isobutyronitrile); bromocatecholborane; hydrogen; trimethylaluminum; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; titanium tetrachloride; sodium hydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; zinc; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; acetonitrile; pentane; 7.1: Diels-Alder reaction;

DOI:10.1248/cpb.60.137

Reference yield:

C41H47NO4S (1370028-21-9) → C50H66O2 (1370028-12-8)

Guidance literature:

Multi-step reaction with 14 steps

1.1: toluene / 7.5 h / 120 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: Crabtree's catalyst; hydrogen / dichloromethane / 48 h / 20 °C / Inert atmosphere

4.1: trimethylaluminum / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 1 h / 0 °C / Inert atmosphere

5.1: tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / 0.67 h / -78 °C / Inert atmosphere

5.2: 1.5 h / Inert atmosphere

6.1: zinc(II) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / diethyl ether / 0.25 h / 0 °C / Inert atmosphere

8.1: sodium hydride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

9.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C / Inert atmosphere

9.2: 0.08 h / 0 °C / Inert atmosphere

10.1: 0.5 h / 0 °C / Inert atmosphere

11.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / 90 °C / Inert atmosphere

12.1: bromocatecholborane / dichloromethane / 1 h / -78 °C / Inert atmosphere

13.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 6 h / 20 °C / Molecular sieve; Inert atmosphere

14.1: titanium tetrachloride; zinc / tetrahydrofuran / 96 h / 0 - 20 °C / Inert atmosphere

14.2: 0.33 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; Crabtree's catalyst; 2,2'-azobis(isobutyronitrile); bromocatecholborane; hydrogen; trimethylaluminum; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; titanium tetrachloride; sodium hydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; zinc; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; acetonitrile; pentane; 6.1: Diels-Alder reaction;

DOI:10.1248/cpb.60.137

upstream raw materials:

C₅₁H₇₀O₄

diiodomethane

C₄₉H₆₄O₃

C₄₁H₄₇NO₄S