(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Base Information

Chemical Name:(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone
CAS No.:1381809-66-0
Molecular Formula:C₃₉H₅₂N₄O₉
Molecular Weight:720.863
Hs Code.:

(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Chemical Property of (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Technology Process of (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

There total 17 articles about (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90819-30-0
(S)-2-((tert-butoxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid

: 1381809-66-0
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 18 h / 20 °C

2.1: 1H-imidazole / acetone / 24 h / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.42 h / 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 18 h

5.1: sodium hydride / tetrahydrofuran / 18 h / 50 °C / Inert atmosphere

6.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.2: 0 °C / Inert atmosphere

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

8.1: Grubbs catalyst first generation / dichloromethane / 24 h / Reflux; Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

Reference yield:

: 1381814-97-6
(S)-1-{(S)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

: 1381809-66-0
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C

3.1: Grubbs catalyst first generation / dichloromethane / 24 h / Reflux; Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1381815-01-5
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((Z)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethyl-nona-6,8-dienoylamino)-3-(4-methoxy-phenyl)-propionylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

: 1381809-66-0
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxy-benzyl)-10,12-dimethoxy-6-(4-methoxy-benzyl)-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation / dichloromethane / 24 h / Reflux; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;