Technology Process of (2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4,4,4-trifluoro-3-methylbutanoic acid
There total 5 articles about (2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4,4,4-trifluoro-3-methylbutanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,3R)-2-((tert-butoxycarbonyl)amino)-4,4,4-trifluoro-3-methyl-butanoic acid;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 3h;
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide;
With
sodium carbonate;
In
1,4-dioxane;
at 0 ℃;
for 3h;
DOI:10.1039/c2ob26810h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C
1.2: 0.13 h / -78 °C
1.3: -78 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C / 750.08 Torr
3.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 0.75 h / 0 °C
4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
4.2: 3 h / 0 °C
With
palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1039/c2ob26810h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C / 750.08 Torr
2.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 0.75 h / 0 °C
3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
3.2: 3 h / 0 °C
With
palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1039/c2ob26810h
