3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide

Base Information

• Chemical Name: 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide
• CAS No.: 1404453-72-0
• Molecular Formula: Br*C₂₀H₃₁N₂O₂
• Molecular Weight: 411.382
• Mol file: 1404453-72-0.mol

Synonyms:

Chemical Property of 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide

There total 3 articles about 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclopentyl-2-hydroxy-2-phenylacetic acid (427-49-6) → 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide (1404453-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 18 h / 60 °C / Inert atmosphere

2.1: propan-1-ol; acetone / 0 - 25 °C / Inert atmosphere

With 1,1'-carbonyldiimidazole; In propan-1-ol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/op3001788

Reference yield:

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester (19833-96-6) → 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide (1404453-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 18 h / 60 °C / Inert atmosphere

3.1: propan-1-ol; acetone / 0 - 25 °C / Inert atmosphere

With 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; propan-1-ol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/op3001788

Reference yield:

methyl bromide (74-83-9) + 2-cyclopentyl-2-hydroxy-N-methyl-N-(1-methylpyrrolidin-3-yl)-2-phenylacetamide (1404453-73-1) → 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)methylamino]-1,1-dimethylpyrrolidinium bromide (1404453-72-0)

Guidance literature:

In propan-1-ol; acetone; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1021/op3001788

upstream raw materials:

methyl bromide

2-cyclopentyl-2-hydroxy-N-methyl-N-(1-methylpyrrolidin-3-yl)-2-phenylacetamide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester

Refernces