(1S)-2,2,2-TRIFLUORO-1-NAPHTHYLETHYLAMINE

Base Information

• Chemical Name: (1S)-2,2,2-TRIFLUORO-1-NAPHTHYLETHYLAMINE
• CAS No.: 1213116-97-2
• Molecular Formula: C₁₂H₁₀F₃N
• Molecular Weight: 225.213
• Mol file: 1213116-97-2.mol

Synonyms:

Chemical Property of (1S)-2,2,2-TRIFLUORO-1-NAPHTHYLETHYLAMINE

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

1-Naphthalenemethanamine,a-(trifluoromethyl)-,(aS)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-2,2,2-TRIFLUORO-1-NAPHTHYLETHYLAMINE

There total 2 articles about (1S)-2,2,2-TRIFLUORO-1-NAPHTHYLETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-4-methoxy-N-(2,2,2-trifluoro-1-(naphthalen-1-yl)ethyl)aniline → C12H10F3N (1213116-97-2,326594-18-7)

Guidance literature:

With silver hexafluoroantimonate; sulfuric acid; [(pyridinooxazoline)PdCl₂]; periodic acid; In water; acetonitrile;

DOI:10.1021/acs.joc.6b00657

Reference yield:

tris(1-naphthyl)boroxine (7519-87-1) → C12H10F3N (1213116-97-2,326594-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: [(pyridinooxazoline)PdCl₂]; silver tetrafluoroborate / 1,2-dichloro-ethane / 20 h / 65 °C / Molecular sieve

2: [(pyridinooxazoline)PdCl₂]; silver hexafluoroantimonate; periodic acid; sulfuric acid / acetonitrile; water

With silver hexafluoroantimonate; silver tetrafluoroborate; sulfuric acid; [(pyridinooxazoline)PdCl₂]; periodic acid; In water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/acs.joc.6b00657

Reference yield:

C12H10F3N (1213116-97-2,326594-18-7) + 3-[3-(trifluoromethyl)phenyl]propanal (21172-41-8) → (R)-N-(2,2,2-trifluoro-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine + (S)-N-(2,2,2-trifluoro-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 1h; Overall yield = 74 %; Overall yield = 61 mg;

DOI:10.1021/acs.joc.6b00657

upstream raw materials:

tris(1-naphthyl)boroxine

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