Technology Process of Pyrimidine, 2-(6-bromo-2-pyridinyl)-
There total 1 articles about Pyrimidine, 2-(6-bromo-2-pyridinyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-Dibromopyridine;
With
n-butyllithium;
In
tetrahydrofuran;
at -70 ℃;
for 0.25h;
Inert atmosphere;
2-bromopyrimidine;
With
zinc(II) chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
for 4h;
Reflux;
- Guidance literature:
-
1-chloro-2-(chloromethyl)benzene;
With
magnesium;
In
diethyl ether;
With
zinc(II) chloride;
In
diethyl ether;
at 20 ℃;
2-(6-bromopyridin-2-yl)pyrimidine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
for 2h;
Heating;
DOI:10.1016/S0040-4039(00)00007-1
- Guidance literature:
-
4-Methylbenzyl chloride;
With
magnesium;
In
diethyl ether;
With
zinc(II) chloride;
In
diethyl ether;
at 20 ℃;
2-(6-bromopyridin-2-yl)pyrimidine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
for 2h;
Heating;
DOI:10.1016/S0040-4039(00)00007-1