((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Base Information

Chemical Name:((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS No.:1683534-96-4
Molecular Formula:C₂₈H₃₂BrF₃N₂O
Molecular Weight:549.474
Hs Code.:

((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Synonyms:

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of ((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

There total 3 articles about ((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 625126-76-3
((1S,3R)-3-amino-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

: 34598-49-7
5-Bromo-1-indanone

: 1683534-96-4
((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.01.063

Reference yield:

: 625126-77-4
tert-butyl ((1R,3S)-3-isopropyl-3-(7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopentyl)carbamate

: 1683534-96-4
((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: titanium(IV) isopropylate / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2015.01.063

Reference yield:

: 624734-30-1
(1S,3R)-3-((tert-butoxycarbonyl)amino)-1-isopropylcyclopentane-1-carboxylic acid

: 1683534-96-4
((1S,3R)-3-((5-bromo-2,3-dihydro-1H-inden-1-yl)amino)-1-isopropylcyclopentyl)(7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; dmap / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: titanium(IV) isopropylate / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2015.01.063