(2-hydroxycyclohexyl)phenylacetic acid

Base Information

• Chemical Name: (2-hydroxycyclohexyl)phenylacetic acid
• CAS No.: 108010-65-7
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295

Synonyms:

Chemical Property of (2-hydroxycyclohexyl)phenylacetic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2-hydroxycyclohexyl)phenylacetic acid

There total 3 articles about (2-hydroxycyclohexyl)phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) + cyclohexane-1,2-epoxide (286-20-4) → (2-hydroxycyclohexyl)phenylacetic acid (108010-65-7)

Guidance literature:

With lithium diethylamide; lithium chloride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1002/ejoc.200300795

Reference yield:

→ trans-2-hydroxycyclohexylphenylacetic acid (108010-65-7)

Guidance literature:

With potassium hydroxide;

Reference yield:

→ (2-hydroxycyclohexyl)phenylacetic acid (108010-65-7)

Guidance literature:

Cyclohexenoxyd + ClMg-Salz der α-Chlormagnesium-phenylessigsaeure ;

DOI:10.1021/jo01075a004

upstream raw materials:

phenylacetic acid

cyclohexane-1,2-epoxide

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