<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Base Information

Chemical Name:<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide
CAS No.:135902-04-4
Molecular Formula:C₃₉H₆₀N₄O₉S
Molecular Weight:760.993
Hs Code.:

<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Synonyms:

Suppliers and Price of <2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

There total 12 articles about <2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 138606-68-5
<2-benzyl-3-(tert-butylsulfonyl)propionyl>-N^im-(2,4-dinitrophenyl)histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

: 135902-04-4,138664-66-1
<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: With thiophenol; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jm00081a019

Reference yield: 33.0%

: 114469-25-9
α-[[(1,1-dimethylethyl)sulfonyl]methyl]benzenepropanoic acid

: 135936-90-2,138664-67-2
histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

: 135902-04-4,138664-66-1
<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 21h; Ambient temperature;
DOI:10.1021/jm00081a019

Reference yield:

: 7757-38-2,14131-84-1,23262-78-4,27108-13-0,33823-04-0,34685-42-2,57819-52-0,78039-08-4,78039-12-0,78964-16-6,94842-76-9,149342-31-4
2,3,5,6-di-O-isopropylidene-D-mannofuranose

: 135902-04-4,138664-66-1
<2-benzyl-3-(tert-butylsulfonyl)propionyl>histidyl <(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4:6,7-di-O-isopropylidene-3,4,5,6,7-pentahydroxyhept-2-yl>amide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-toluenesulfonic acid / 24 h / Heating

2: 1.) Li / 1.) Et₂O, -10 deg C, 6 h, 2.) Et₂O, RT, 1 h

3: 85 percent / ammonium formate / 10percent Pd/C / methanol / 20 h / Ambient temperature

4: 1.) pivaloyl chloride, N-ethylpiperidine, Et₃N / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 20 h

5: 47 percent / thiophenol / acetonitrile / 2 h / Ambient temperature

With 1-ethyl-piperidine; ammonium formate; pivaloyl chloride; lithium; toluene-4-sulfonic acid; thiophenol; triethylamine; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00081a019