Cyclopropanecarboxaldehyde, 2-methyl-, cis-

Base Information

• Chemical Name: Cyclopropanecarboxaldehyde, 2-methyl-, cis-
• CAS No.: 139765-03-0
• Molecular Formula: C₅H₈O
• Molecular Weight: 84.1179
• Mol file: 139765-03-0.mol

Synonyms:

Chemical Property of Cyclopropanecarboxaldehyde, 2-methyl-, cis-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxaldehyde, 2-methyl-, cis-

There total 6 articles about Cyclopropanecarboxaldehyde, 2-methyl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

trans-1-(hydroxymethyl)-2-methylcyclopropane (21003-36-1) → trans-2-methyl-cyclopropanecarboxaldehyde (39547-01-8,50991-21-4,126110-29-0,139765-03-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;

Reference yield: 68.0%

dibutyl 2-(trans-2-methylcyclopropyl)-1,3-dioxolane-trans-4,5-dicarboxylate → trans-2-methyl-cyclopropanecarboxaldehyde (39547-01-8,50991-21-4,126110-29-0,139765-03-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 25 ℃; for 48h;

DOI:10.1007/s11172-005-0348-7

Reference yield: 35.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + trans-Crotonaldehyde (123-73-9,4170-30-3) → trans-2-methyl-cyclopropanecarboxaldehyde (39547-01-8,50991-21-4,126110-29-0,139765-03-0)

Guidance literature:

With palladium(II) acetylacetonate; In diethyl ether;

DOI:10.1007/s11172-005-0348-7

upstream raw materials:

trans-1-(hydroxymethyl)-2-methylcyclopropane

diazomethane

trans-Crotonaldehyde

(+/-)-trans-2-methylcyclopropanecarboxylic acid

Refernces

• 1、 Nakamura, Itaru,Okamoto, Masashi,Sato, Yoshinori,Terada, Masahiro. "Synthesis of azepine derivatives by rhodium-catalyzed tandem 2,3-rearrangement/heterocyclization". supporting information. p. 10816 - 10819. Retrieved 2013/01/15.
• 2、 Wu, Pei-Lin,Wang, Wen-Shan. "Thermal Ring-Expansion of N-Acyl Cyclopropyl Imines". . p. 622 - 627. Retrieved 2007/10/02.