{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester
CAS No.:225378-75-6
Molecular Formula:C₃₆H₅₂Cl₃N₅O₇S
Molecular Weight:805.263
Hs Code.:

{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of {4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

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Technology Process of {4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

There total 10 articles about {4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: N-benzyl-N-dimethylcarbamoylmethyl-2-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-ylmethyl]-succinamic acid

: 225378-75-6
{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 3.5h; Yield given;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 111605-82-4
N,N-dimethyl-2-<(phenylmethyl)amino>acetamide

: 225378-75-6
{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 h / 25 °C

2: 30 percent H₂O₂, LiOH*H₂O / H₂O; trifluoroacetic acid / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, 3.5 h

3: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 3.5 h / 25 °C

With lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: benzyl-dimethylcarbamoylmethyl-carbamic acid tert-butyl ester

: 225378-75-6
{4-[(R)-3-(Benzyl-dimethylcarbamoylmethyl-carbamoyl)-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4N HCl / ethyl acetate / 25 °C

2: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 h / 25 °C

3: 30 percent H₂O₂, LiOH*H₂O / H₂O; trifluoroacetic acid / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, 3.5 h

4: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 3.5 h / 25 °C

With hydrogenchloride; lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1016/S0968-0896(98)00265-X