1-amino-1-methylethylphosphinic acid

Base Information

• Chemical Name: 1-amino-1-methylethylphosphinic acid
• CAS No.: 65576-89-8
• Molecular Formula: C₃H₁₀NO₂P
• Molecular Weight: 123.092
• Mol file: 65576-89-8.mol

Synonyms:

Chemical Property of 1-amino-1-methylethylphosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-amino-1-methylethylphosphinic acid

There total 2 articles about 1-amino-1-methylethylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 0.7%

ethyl 3-oxobutanate oxime (5447-76-7) → 1-amino-1-methylethylphosphinic acid (65576-89-8) + 3-amino-3-hydrohydroxyphosphorylbutyric acid (94650-45-0)

Guidance literature:

ethyl 3-oxobutanate oxime; With hypophosphorous acid; In ethanol; for 21h; Heating;

With hydrogenchloride; water; for 3h; Heating;

DOI:10.1007/BF01457787

Reference yield:

3-amino-3-hydroxyphosphinoyl-butyric acid ethyl ester → 1-amino-1-methylethylphosphinic acid (65576-89-8) + 3-amino-3-hydrohydroxyphosphorylbutyric acid (94650-45-0)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1007/BF01431122

Reference yield: 79.0%

1-amino-1-methylethylphosphinic acid (65576-89-8) → (2-aminopropane-2-yl)phosphonic acid (5035-79-0,90735-61-8)

Guidance literature:

With hydrogenchloride; bromine; In water; at 20 ℃; for 0.5h;

DOI:10.1007/BF01457787

upstream raw materials:

ethyl 3-oxobutanate oxime

Downstream raw materials:

(2-aminopropane-2-yl)phosphonic acid

Refernces

• 1、 Osipova,Belyankin,Khomutov,Zhukov,Khurs,Khomutov. "Synthesis of α-substituted α-aminophosphinic and α-aminophosphonic acids". . p. 2588 - 2591. Retrieved 2007/10/03.