Technology Process of benzhydrylidene[6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl]amine
There total 3 articles about benzhydrylidene[6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl]amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane;
Sealed tube;
Inert atmosphere;
Reflux;
DOI:10.1055/s-0030-1260110
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bromine / N,N-dimethyl-formamide / 0 - 20 °C
2: toluene-4-sulfonic acid / ethyl acetate / Reflux
3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Sealed tube; Inert atmosphere; Reflux
With
bromine; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
3: Buchwald-Hartwig C-N coupling reaction;
DOI:10.1055/s-0030-1260110
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / ethyl acetate / Reflux
2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Sealed tube; Inert atmosphere; Reflux
With
palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; ethyl acetate;
2: Buchwald-Hartwig C-N coupling reaction;
DOI:10.1055/s-0030-1260110
