ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

Base Information

Chemical Name:ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate
CAS No.:1426333-02-9
Molecular Formula:C₂₈H₃₃N₃O₆
Molecular Weight:507.587
Hs Code.:

ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

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Chemical Property of ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

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Technology Process of ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

There total 3 articles about ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 66130-92-5
3-chlorocarbonylacrylic acid ethyl ester

: 1407674-65-0
(3S,5S)-5-benzyl-3-(4-isopropyl-5-morpholinooxazol-2-yl)-3-methylmorpholin-2-one

: 1426333-02-9
ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 110 ℃; for 20h; Molecular sieve; Inert atmosphere;
DOI:10.1021/jo4000702

Reference yield:

: 3-methyl-2-(morpholine-4-carbonyl)-butyronitrile

: 1426333-02-9
ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: phenylphosphinic acid / 2,2,2-trifluoroethanol / 1.25 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 20 h / 110 °C / Molecular sieve; Inert atmosphere

With phenylphosphinic acid; N-ethyl-N,N-diisopropylamine; In 2,2,2-trifluoroethanol; toluene; 1: |Ugi Condensation;
DOI:10.1021/jo4000702

Reference yield:

: 1355545-47-9
C₁₂H₁₃NO₂

: 1426333-02-9
ethyl (7S,10aS)-7-benzyl-2-isopropyl-10a-methyl-3-morpholino-5,10-dioxo-7,8,10,10a-tetrahydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: phenylphosphinic acid / 2,2,2-trifluoroethanol / 1.25 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 20 h / 110 °C / Molecular sieve; Inert atmosphere

With phenylphosphinic acid; N-ethyl-N,N-diisopropylamine; In 2,2,2-trifluoroethanol; toluene; 1: |Ugi Condensation;
DOI:10.1021/jo4000702