Technology Process of Acetic acid 2-{(1R,3R,6R)-2,2,6-trimethyl-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-cyclohexyl}-ethyl ester
There total 14 articles about Acetic acid 2-{(1R,3R,6R)-2,2,6-trimethyl-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-cyclohexyl}-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridinium p-toluenesulfonate / CH2Cl2 / 13 h / Ambient temperature
2: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature
3: 176 mg / 1.) LiAlH4; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C
4: 179 mg / pyridine / 1 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride;
In
pyridine; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1248/cpb.36.4711
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 70.5 percent / toluene / 24 h / 100 °C
2: 97.3 percent / PtO2, hydrogen / ethyl acetate / 2 h / Ambient temperature
3: 100 percent / Et3N / CH2Cl2 / 0.33 h / 0 °C
4: dimethylsulfoxide / 7 h / 100 - 105 °C
5: 240 mg / LiBH4 / diethyl ether / 3 h / Heating
6: pyridinium p-toluenesulfonate / CH2Cl2 / 13 h / Ambient temperature
7: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature
8: 176 mg / 1.) LiAlH4; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C
9: 179 mg / pyridine / 1 h / Ambient temperature
With
platinum(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; water; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine;
In
pyridine; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.36.4711
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridinium p-toluenesulfonate / CH2Cl2 / 13 h / Ambient temperature
2: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature
3: 176 mg / 1.) LiAlH4; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C
4: 179 mg / pyridine / 1 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride;
In
pyridine; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1248/cpb.36.4711
