methyl 4-(bromoethynyl)-2,3-dimethylbenzoate

Base Information

• Chemical Name: methyl 4-(bromoethynyl)-2,3-dimethylbenzoate
• CAS No.: 1427286-62-1
• Molecular Formula: C₁₂H₁₁BrO₂
• Molecular Weight: 267.122
• Mol file: 1427286-62-1.mol

Synonyms:

Chemical Property of methyl 4-(bromoethynyl)-2,3-dimethylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(bromoethynyl)-2,3-dimethylbenzoate

There total 1 articles about methyl 4-(bromoethynyl)-2,3-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2,3-dimethylphenol (22802-37-5) → methyl 4-(bromoethynyl)-2,3-dimethylbenzoate (1427286-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 15 h / 25 °C / Inert atmosphere

2: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / dimethyl sulfoxide / 16 h / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;

DOI:10.1039/c3cc38676g

upstream raw materials:

4-bromo-2,3-dimethylphenol

Refernces