4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Base Information

• Chemical Name: 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine
• CAS No.: 137212-08-9
• Molecular Formula: C₆H₁₅N*C₃₅H₃₅ClN₃O₁₁P
• Molecular Weight: 841.295

Synonyms:

Chemical Property of 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

There total 4 articles about 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-Methyl-benzoic acid (2R,3R,4R,5R)-3-[(2-benzenesulfonyl-ethoxy)-(2-chloro-phenoxy)-phosphoryloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester (137212-06-7) + triethylamine (121-44-8) → 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (137212-08-9)

Guidance literature:

With pyridine; for 0.75h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86562-5

Reference yield:

N-4-benzoyl-5'-O-pixyl-2'-O-tetrahydropyranylcytidine-3'-O-triethylammonium(2-chlorophenyl)phosphate (137211-97-3) → 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (137212-08-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / pyridine, 1-mesitylenesulfonyl-3-nitro-1,2,4-triazole (MSNT) / 0.75 h / Ambient temperature

2: 72 percent / 0.2 M trichloroacetic acid / ethanol; CHCl₃ / 3 h / 0 °C

3: 96 percent / pyridine / 3 h / Ambient temperature

4: 91 percent / pyridine / 0.75 h / Ambient temperature

With pyridine; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; trichloroacetic acid; In ethanol; chloroform;

DOI:10.1016/S0040-4020(01)86562-5

Reference yield:

Phosphoric acid 2-benzenesulfonyl-ethyl ester (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (137212-04-5) → 4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (137212-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 0.2 M trichloroacetic acid / ethanol; CHCl₃ / 3 h / 0 °C

2: 96 percent / pyridine / 3 h / Ambient temperature

3: 91 percent / pyridine / 0.75 h / Ambient temperature

With pyridine; trichloroacetic acid; In ethanol; chloroform;

DOI:10.1016/S0040-4020(01)86562-5

upstream raw materials:

4-Methyl-benzoic acid (2R,3R,4R,5R)-3-[(2-benzenesulfonyl-ethoxy)-(2-chloro-phenoxy)-phosphoryloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

triethylamine

Phosphoric acid 2-benzenesulfonyl-ethyl ester (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Phosphoric acid 2-benzenesulfonyl-ethyl ester (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

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