(S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester

Base Information

• Chemical Name: (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester
• CAS No.: 100573-79-3
• Molecular Formula: C₂₆H₄₁N₃O₇
• Molecular Weight: 507.627
• Mol file: 100573-79-3.mol

Synonyms:

Chemical Property of (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester

There total 2 articles about (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-6-tert-butoxycarbonylamino-hexanoic acid methyl ester (100603-66-5) → (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester (100573-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C (10 percent) / methanol / 4 h

2: Et₃N, propylphosphonic anhydride / CH₂Cl₂ / 4 h / Ambient temperature

With propylphosphonic anhydride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

(S)-2-amino-butyric acid benzyl ester; hydrochloride + (S)-6-tert-Butoxycarbonylamino-2-((R)-1-carboxy-ethylamino)-hexanoic acid methyl ester (100573-71-5) → (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester (100573-79-3)

Guidance literature:

With propylphosphonic anhydride; triethylamine; In dichloromethane; for 4h; Yield given; Ambient temperature;

Reference yield:

(S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid methyl ester (100573-79-3) → (S)-6-tert-Butoxycarbonylamino-2-[(R)-1-((R)-1-carboxy-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid

Guidance literature:

With sodium hydroxide; In acetone; for 32h;

upstream raw materials:

(S)-6-tert-Butoxycarbonylamino-2-((R)-1-carboxy-ethylamino)-hexanoic acid methyl ester

(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-6-tert-butoxycarbonylamino-hexanoic acid methyl ester

Downstream raw materials:

(S)-6-Amino-2-[(R)-1-((R)-1-carboxy-2-phenyl-ethylcarbamoyl)-ethylamino]-hexanoic acid