p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate

Base Information

• Chemical Name: p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate
• CAS No.: 105076-09-3
• Molecular Formula: C₂₁H₂₁N₅O₆S
• Molecular Weight: 471.494

Synonyms:

Chemical Property of p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate

There total 4 articles about p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + p-nitrobenzyl (5R)-3-<(E)-2-acetamidoethenylthio>-6-(E)-ethylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate (73521-60-5) → p-nitrobenzyl (4'R,5R,6R)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3) + p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3)

Guidance literature:

In diethyl ether; dichloromethane; for 20h; Ambient temperature;

Reference yield: 10.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + p-nitrobenzyl (5R)-3-<(E)-2-acetamidoethenylthio>-6-(E)-ethylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate (73521-60-5) → p-nitrobenzyl (4'R,5R,6R)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3) + p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3)

Guidance literature:

In diethyl ether; dichloromethane; for 20h; Ambient temperature;

Reference yield: 7.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + p-nitrobenzyl (5R)-3-<(E)-2-acetamidoethenylthio>-6-(Z)-ethylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate (73521-59-2) → p-nitrobenzyl (4'R,5R,6R)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3) + p-nitrobenzyl (4'R,5R,6S)-3-<(E)-2-acetamidovinylthio>-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate (105076-09-3,105119-89-9,105119-90-2,105119-91-3)

Guidance literature:

In diethyl ether; dichloromethane; for 24h; Ambient temperature;

upstream raw materials:

diazomethane

p-nitrobenzyl (5R)-3-<(E)-2-acetamidoethenylthio>-6-(E)-ethylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

p-nitrobenzyl (5R)-3-<(E)-2-acetamidoethenylthio>-6-(Z)-ethylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Downstream raw materials:

p-nitrobenzyl (5R)-3-<(E)-2-acetamidovinylthio>pyrrole-2-carboxylate

p-nitrobenzyl (5R)-3-<(E)-2-acetamidovinylthio>-6-isopropylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

C₁₇H₁₆N₄O₅S

p-nitrobenzyl (4'R,5R,6R)-4'methyl-3-(N-p-nitrobenzyloxycarbonyl-N',N'-dimethylcarmbamimidoylmethylthio)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate

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