5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester

Base Information

• Chemical Name: 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester
• CAS No.: 87957-83-3
• Molecular Formula: C₂₁H₂₈N₂O₂
• Molecular Weight: 340.466
• Mol file: 87957-83-3.mol

Synonyms:

Chemical Property of 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester

There total 7 articles about 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-Phenylspiro<2.6>non-1-en-1-carbonsaeure-tert-butylester (87957-69-5) → 1'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-5'-carbonsaeure-tert-butylester (87957-84-4) + 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester (87957-83-3)

Guidance literature:

In diethyl ether; 1) 0 deg C, 30 min, 2) r.t., 30 min;

Reference yield:

(Cycloheptylidenmethyl)benzol (15537-53-8) → 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester (87957-83-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 77 percent

2: 1) BuLi

3: 92 percent / conc. H₂SO₄ / 48 h / 70 °C

4: 66 percent / KOtBu / tetrahydrofuran / 1) 30 min, 0 deg C, 2) 3 h, r.t.

5: 50 percent / diethyl ether / 1) 0 deg C, 30 min, 2) r.t., 30 min

With n-butyllithium; sulfuric acid; potassium tert-butylate; In tetrahydrofuran; diethyl ether;

Reference yield:

cycloheptyltriphenylphosphonium bromide (22836-06-2) → 5'-Phenylspirodiazabicyclo<3.1.0>hex-2-en>-1'-carbonsaeure-tert-butylester (87957-83-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 48 percent / 20percent BuLi / tetrahydrofuran; hexane / 6 h / Heating

2: 77 percent

3: 1) BuLi

4: 92 percent / conc. H₂SO₄ / 48 h / 70 °C

5: 66 percent / KOtBu / tetrahydrofuran / 1) 30 min, 0 deg C, 2) 3 h, r.t.

6: 50 percent / diethyl ether / 1) 0 deg C, 30 min, 2) r.t., 30 min

With n-butyllithium; sulfuric acid; potassium tert-butylate; In tetrahydrofuran; diethyl ether; hexane;

upstream raw materials:

diazomethane

2-Phenylspiro<2.6>non-1-en-1-carbonsaeure-tert-butylester

(Cycloheptylidenmethyl)benzol

cycloheptyltriphenylphosphonium bromide