(R)-3-TERT-BUTOXYCARBONYLAMINOHEXANOIC ACID

Base Information

• Chemical Name: (R)-3-TERT-BUTOXYCARBONYLAMINOHEXANOIC ACID
• CAS No.: 158807-49-9
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.292
• Mol file: 158807-49-9.mol

Synonyms:

Chemical Property of (R)-3-TERT-BUTOXYCARBONYLAMINOHEXANOIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-((tert-Butoxycarbonyl)amino)hexanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-TERT-BUTOXYCARBONYLAMINOHEXANOIC ACID

There total 6 articles about (R)-3-TERT-BUTOXYCARBONYLAMINOHEXANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

[(R)-1-(2-Hydroxy-ethyl)-butyl]-carbamic acid tert-butyl ester (158807-46-6) → (R)-3-tert-Butoxycarbonylamino-hexanoic acid (158807-49-9)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 25 ℃; for 1h;

DOI:10.1016/0040-4039(96)00518-7

Reference yield:

(S)-4-(2-Hydroxy-ethyl)-5-vinyl-oxazolidin-2-one → (R)-3-tert-Butoxycarbonylamino-hexanoic acid (158807-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 4 h / 25 °C / 760 Torr

2: NaHCO₃ / ethyl acetate; H₂O

3: 77 percent / 6 molpercent RuCl₃*xH₂O, NaIO₄ / acetonitrile; CCl₄; H₂O / 1 h / 25 °C

With ruthenium trichloride; sodium periodate; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; tetrachloromethane; water; ethyl acetate; acetonitrile;

DOI:10.1016/0040-4039(96)00518-7

Reference yield:

(-)-(3R)-3-Aminohexanol (64197-81-5,64197-80-4) → (R)-3-tert-Butoxycarbonylamino-hexanoic acid (158807-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / ethyl acetate; H₂O

2: 77 percent / 6 molpercent RuCl₃*xH₂O, NaIO₄ / acetonitrile; CCl₄; H₂O / 1 h / 25 °C

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; In tetrachloromethane; water; ethyl acetate; acetonitrile;

DOI:10.1016/0040-4039(96)00518-7

upstream raw materials:

[(R)-1-(2-Hydroxy-ethyl)-butyl]-carbamic acid tert-butyl ester

(-)-(3R)-3-Aminohexanol

[(R)-1-((R)-1,2-Dihydroxy-ethyl)-butyl]-carbamic acid tert-butyl ester

((R)-1-Vinyl-butyl)-carbamic acid tert-butyl ester