C₂₈H₂₈FNO₃S

Base Information

• Chemical Name: C₂₈H₂₈FNO₃S
• CAS No.: 1363722-13-7
• Molecular Formula: C₂₈H₂₈FNO₃S
• Molecular Weight: 477.6
• Mol file: 1363722-13-7.mol

Synonyms:

Chemical Property of C₂₈H₂₈FNO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₈FNO₃S

There total 2 articles about C₂₈H₂₈FNO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H15NO2 (791814-82-9) + 1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene (1311404-00-8) → C28H28FNO3S (1363722-13-7) + C28H28FNO3S (1363722-24-0)

Guidance literature:

1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

C₁₄H₁₅NO₂; In tetrahydrofuran; hexane; at -78 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo300174k

Reference yield:

C20H18O4S2 → C28H28FNO3S (1363722-13-7) + C28H28FNO3S (1363722-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium fluoride / acetonitrile / Ionic liquid; Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; cesium fluoride; In tetrahydrofuran; hexane; acetonitrile; 2.1: Michael condensation / 2.2: Michael condensation;

DOI:10.1021/jo300174k

upstream raw materials:

C₁₄H₁₅NO₂

1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene