C₂₄H₂₀FN₅OS

Base Information

Chemical Name:C₂₄H₂₀FN₅OS
CAS No.:1400771-86-9
Molecular Formula:C₂₄H₂₀FN₅OS
Molecular Weight:445.52
Hs Code.:

C<sub>24</sub>H<sub>20</sub>FN<sub>5</sub>OS

Synonyms:

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Chemical Property of C₂₄H₂₀FN₅OS

Chemical Property:

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Technology Process of C₂₄H₂₀FN₅OS

There total 13 articles about C₂₄H₂₀FN₅OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₈FN₅O₃S

: 1400771-86-9
C₂₄H₂₀FN₅OS

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm301039c

Reference yield:

: 917772-62-4
C₂₃H₃₁BrN₂O₄SSi

: 1400771-86-9
C₂₄H₂₀FN₅OS

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride / 1,4-dioxane / 14 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 48 h / 20 °C

3: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 1.5 h / -15 - 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 °C

5: isopropyl alcohol / hexane / Resolution of racemate

6: potassium carbonate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane / water; tert-butyl alcohol / 1 h / 60 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8: copper diacetate; triethylamine / dichloromethane / 48 h / 20 °C / Molecular sieve

9: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane; carbonochloridic acid 1-chloro-ethyl ester; tetrabutyl ammonium fluoride; copper diacetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; tert-butyl alcohol; 6: |Suzuki Coupling / 8: |Suzuki Coupling;
DOI:10.1021/jm301039c

Reference yield:

: 1192479-42-7
C₁₆H₂₁BrN₄O₃S

: 1400771-86-9
C₂₄H₂₀FN₅OS

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 °C

2: isopropyl alcohol / hexane / Resolution of racemate

3: potassium carbonate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane / water; tert-butyl alcohol / 1 h / 60 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

5: copper diacetate; triethylamine / dichloromethane / 48 h / 20 °C / Molecular sieve

6: trifluoroacetic acid / dichloromethane / 20 °C

With dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium dichloromethane; tetrabutyl ammonium fluoride; copper diacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol; 3: |Suzuki Coupling / 5: |Suzuki Coupling;
DOI:10.1021/jm301039c