2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid

Base Information

• Chemical Name: 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid
• CAS No.: 1584731-72-5
• Molecular Formula: C₃₃H₃₉Cl₂N₃O₅S
• Molecular Weight: 660.662
• Mol file: 1584731-72-5.mol

Synonyms:

Chemical Property of 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid

There total 6 articles about 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H43Cl2N3O5S (1584732-07-9) → 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid (1584731-72-5)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm401911v

Reference yield:

2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile (1584731-78-1) → 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid (1584731-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 20 °C / Inert atmosphere

2: ammonia / ethanol / 20 °C / Inert atmosphere

3: acetonitrile / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

4: lithium hydroxide; methanol / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

With hydrogenchloride; methanol; ammonia; lithium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1021/jm401911v

Reference yield:

1-amino-2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)ethaniminium (1584731-80-5) → 2-(2-(((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)-1H-imidazol-4-yl)acetic acid (1584731-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2: lithium hydroxide; methanol / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

With methanol; lithium hydroxide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm401911v

upstream raw materials:

2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

ethyl 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetimidate

C₃₅H₄₃Cl₂N₃O₅S

1-amino-2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)ethaniminium