cis-5-methylproline

Base Information

• Chemical Name: cis-5-methylproline
• CAS No.: 13532-74-6
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 13532-74-6.mol

Synonyms:

Chemical Property of cis-5-methylproline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-5-methylproline

There total 6 articles about cis-5-methylproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-oxo-2-[N-(9-(9-phenylfluorenyl))amino]hexanoate (296775-02-5) → cis-5-methylproline (7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

2: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

3: TFA / CH₂Cl₂

With potassium trimethylsilonate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;

DOI:10.1139/v00-176

Reference yield:

5-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-hexanoic acid → cis-5-methylproline (7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 259 mg / K₂CO₃ / acetonitrile / 18 h / 20 °C

2: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

3: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

4: TFA / CH₂Cl₂

With potassium trimethylsilonate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1139/v00-176

Reference yield:

methyl 5-oxo-4-(methyloxycarbonyl)-2-[N-(9-phenylfluoren-9-yl)amino]hexanoate (296774-83-9) → cis-5-methylproline (7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1N NaOH / ethanol / 5 h / Heating

2: 259 mg / K₂CO₃ / acetonitrile / 18 h / 20 °C

3: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

4: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

5: TFA / CH₂Cl₂

With sodium hydroxide; potassium trimethylsilonate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; acetonitrile;

DOI:10.1139/v00-176

upstream raw materials:

ethyl cis-5-methylpyrrolidine-2-carboxylate

cis-N-(Boc)-5-methylproline

cis-N-(Boc)-5-methylproline methyl ester

methyl 5-oxo-2-[N-(9-(9-phenylfluorenyl))amino]hexanoate