C₃₀H₃₁BrN₂O₃

Base Information

• Chemical Name: C₃₀H₃₁BrN₂O₃
• CAS No.: 125049-29-8
• Molecular Formula: C₃₀H₃₁BrN₂O₃
• Molecular Weight: 547.492
• Mol file: 125049-29-8.mol

Synonyms:

Chemical Property of C₃₀H₃₁BrN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₁BrN₂O₃

There total 5 articles about C₃₀H₃₁BrN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-10,11-dihydro-5-methyl-5H-dibenzo[a,d]-cyclohepten-5,10-imine (111305-45-4) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → C30H31BrN2O3 (125049-29-8,125134-18-1)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃; for 120h;

DOI:10.1021/jm00164a052

Reference yield:

12-hydroxy-3-bromo-5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine (87747-42-0) → C30H31BrN2O3 (125049-29-8,125134-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Ac₂O, 2.) BH₃*THF / 1.) 2 h, 2.) a) THF, 0 deg C, b) reflux, 3 d

2: 2.9 g / diisopropylethylamine (DIPEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 120 h / 0 - 5 °C

With borane-THF; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm00164a052

Reference yield:

3-bromo-5H-dibenzo[a,d]cyclohepten-5-one (3979-65-5) → C30H31BrN2O3 (125049-29-8,125134-18-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

2: 63 percent / NH₂OH*HCl, NaOAc, Cl₂CHCO₂H / CH₂Cl₂ / 48 h / Heating

3: potassium tert-butoxide / toluene; dimethylsulfoxide / 0.25 h / 55 °C

4: 1.) Ac₂O, 2.) BH₃*THF / 1.) 2 h, 2.) a) THF, 0 deg C, b) reflux, 3 d

5: 2.9 g / diisopropylethylamine (DIPEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 120 h / 0 - 5 °C

With dichloro-acetic acid; borane-THF; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00164a052

upstream raw materials:

3-bromo-10,11-dihydro-5-methyl-5H-dibenzo[a,d]-cyclohepten-5,10-imine

N-tert-butoxycarbonyl-L-phenylalanine

12-hydroxy-3-bromo-5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine

3-bromo-5H-dibenzo[a,d]cyclohepten-5-one

Downstream raw materials:

(5R,10S)-(-)-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine

(5S,10R)-(+)-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine

(5S,10R)-L-phenylalanyl-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine

(5R,10S)-L-phenylalanyl-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine

Refernces