Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-6-thio-, 3'-acetate

Base Information

• Chemical Name: Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-6-thio-, 3'-acetate
• CAS No.: 139887-94-8
• Molecular Formula: C₃₉H₄₂N₄O₈S
• Molecular Weight: 726.85
• Mol file: 139887-94-8.mol

Synonyms:

Chemical Property of Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-6-thio-, 3'-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-6-thio-, 3'-acetate

There total 8 articles about Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-6-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-6-thio-, 3'-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2,2-Dimethyl-propionic acid 9-{(2R,4S,5R)-4-acetoxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylsulfanylmethyl ester (139887-94-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) pyridine / 1) room temperature, overnight; 2) room temperature, 2 h

2: 63 percent / Et₃N, POCl₃ / acetonitrile / 48 h / Ambient temperature

3: sodium hydrogen sulfide / dimethylformamide / 6 h / Ambient temperature

4: potassium carbonate / acetone / Ambient temperature

With pyridine; sodium hydrogensulfide; potassium carbonate; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

Chloromethyl pivalate (18997-19-8) → 2,2-Dimethyl-propionic acid 9-{(2R,4S,5R)-4-acetoxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylsulfanylmethyl ester (139887-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: acetylation

With potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)77675-1

Reference yield:

6-mercaptopurine-2’-deoxyribose (2239-64-7) → 2,2-Dimethyl-propionic acid 9-{(2R,4S,5R)-4-acetoxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylsulfanylmethyl ester (139887-94-8)

Guidance literature:

Multi-step reaction with 3 steps

2: K₂CO₃ / acetone

3: acetylation

With potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)77675-1

upstream raw materials:

2,2-Dimethyl-propionic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-ylsulfanylmethyl ester

2-deoxyinosine

4,4'-dimethoxytrityl chloride

3'-O-acetyl-5'-O-dimethoxytrityl-2'-deoxyinosine