(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Base Information

Chemical Name:(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester
CAS No.:118437-02-8
Molecular Formula:C₃₅H₄₈O₆Si
Molecular Weight:592.848
Hs Code.:

(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Synonyms:

Suppliers and Price of (3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

There total 14 articles about (3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111649-67-3,118490-70-3,118490-71-4,118490-72-5,118490-75-8,118490-76-9,118490-77-0
(3aS,4R,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-2,2,4-trimethyl-5-oxo-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

: 118419-06-0
(3aS,4S,5R,5aR,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-6-hydroxymethyl-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxol-5-ol

: 118437-02-8
(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

: 111649-68-4,118490-78-1
(3R,3aS,6S,6aS,9aR,9bS,9cS)-3-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-6,8,8-trimethyl-3,3a,5a,6,6a,9a,9b,9c-octahydro-5,7,9-trioxa-cyclopenta[e]acenaphthylen-4-one

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃;
DOI:10.1021/jo00265a036

Reference yield:

: 88424-95-7
2,3-O-isopropylidene-1-C-<(1S)-1-methylprop-2-enyl>-D-erythro-glycerol

: 118437-02-8
(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: AcOH / H₂O

2: Et₃N, DMAP / CH₂Cl₂

3: p-TsOH

4: 1.) ozone, 2.) Me₂S / 1.) methanol, -78 deg C, 2.) 2 h

5: MCPBA / CH₂Cl₂ / 1 h

6: CH₂Cl₂; diethyl ether

7: 88 percent / Et₃NHF / acetonitrile

8: DMSO, (COCl)2 / CH₂Cl₂ / 0.17 h / -78 °C

10: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 40 min, 2.) 10 min

11: 57 percent / LiCl, diisopropylethylamine / acetonitrile / 0.08 h

12: 17 percent / I₂ / hexane / 48 h / 23 °C

13: NaBH₄ / ethanol / 0 °C

With dmap; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; dimethylsulfide; iodine; toluene-4-sulfonic acid; ozone; acetic acid; dimethyl sulfoxide; triethylamine hydrofluoride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium chloride; In diethyl ether; ethanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00265a036

Reference yield:

: (R)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-propionaldehyde

: 118437-02-8
(3aS,4S,5aS,6S,7R,9aS,9bR)-7-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-5-hydroxy-2,2,4-trimethyl-3a,4,5,5a,6,7,9a,9b-octahydro-naphtho[1,2-d][1,3]dioxole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: MCPBA / CH₂Cl₂ / 1 h

2: CH₂Cl₂; diethyl ether

3: 88 percent / Et₃NHF / acetonitrile

4: DMSO, (COCl)2 / CH₂Cl₂ / 0.17 h / -78 °C

6: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 40 min, 2.) 10 min

7: 57 percent / LiCl, diisopropylethylamine / acetonitrile / 0.08 h

8: 17 percent / I₂ / hexane / 48 h / 23 °C

9: NaBH₄ / ethanol / 0 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; iodine; dimethyl sulfoxide; triethylamine hydrofluoride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium chloride; In diethyl ether; ethanol; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jo00265a036