Technology Process of 3,5-Dimethoxy-(7S)-<7-(2)H,7-(3)H>toluene
There total 6 articles about 3,5-Dimethoxy-(7S)-<7-(2)H,7-(3)H>toluene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Supertritide; lithium triethylborohydride;
In
tetrahydrofuran;
for 3.5h;
Yield given;
Ambient temperature;
DOI:10.1021/jo00168a027
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-Butyllithium, 2.) D2O (99.8 percent (2)H) / 1.) THF/hexane, -70 deg C, 1 h, 2.) 2 h, room temp.
2: 88.1 percent / HgO/HgCl2 / methanol; H2O / 2 h / 80 - 85 °C
3: 83.4 percent / 1.) (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1.) 15 h, room temp., 2.) reflux, 1 h
4: 1.) NaH/mineral oil
5: Superhydride/Supertritide / tetrahydrofuran / 3.5 h / Ambient temperature
With
n-butyllithium; (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane; Supertritide; water-d2; sodium hydride; lithium triethylborohydride; mercury dichloride; mercury(II) oxide; mineral oil;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/jo00168a027
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75.8 percent / HCl gas / CHCl3 / 18 h / Ambient temperature
2: 1.) n-Butyllithium, 2.) D2O (99.8 percent (2)H) / 1.) THF/hexane, -70 deg C, 1 h, 2.) 2 h, room temp.
3: 88.1 percent / HgO/HgCl2 / methanol; H2O / 2 h / 80 - 85 °C
4: 83.4 percent / 1.) (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1.) 15 h, room temp., 2.) reflux, 1 h
5: 1.) NaH/mineral oil
6: Superhydride/Supertritide / tetrahydrofuran / 3.5 h / Ambient temperature
With
hydrogenchloride; n-butyllithium; (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane; Supertritide; water-d2; sodium hydride; lithium triethylborohydride; mercury dichloride; mercury(II) oxide; mineral oil;
In
tetrahydrofuran; methanol; chloroform; water;
DOI:10.1021/jo00168a027
