Technology Process of allyl-Tyr-D-Ala-Phe-Gly-Phe-NH2
There total 4 articles about allyl-Tyr-D-Ala-Phe-Gly-Phe-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; methoxybenzene;
for 0.666667h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / H2 / 10percent Pd-charcoal / acetic acid / 3 h / Ambient temperature
2: 1.) isobutyl chloroformate, NMM / 1.) DMF, -10 deg C, 3 min, 2.) DMF-THF, -10 deg C, 1h than 0-10 deg C, 3 h
3: 1.) 90percent TFA, anisole, 2) NMM, HOBt, DCCI / 1.) 40 min, 2.) DMF, 0 deg C, 2 h than r.t., 24 h
4: 88 percent / anisole, water / 0.67 h
With
4-methyl-morpholine; water; hydrogen; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) isobutyl chloroformate, NMM / 1.) DMF, -10 deg C, 3 min, 2.) DMF-THF, -10 deg C, 1h than 0-10 deg C, 3 h
2: 1.) 90percent TFA, anisole, 2) NMM, HOBt, DCCI / 1.) 40 min, 2.) DMF, 0 deg C, 2 h than r.t., 24 h
3: 88 percent / anisole, water / 0.67 h
With
4-methyl-morpholine; water; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate;
