C₆₆H₁₀₅N₅O₁₇Si

Base Information

Chemical Name:C₆₆H₁₀₅N₅O₁₇Si
CAS No.:383910-61-0
Molecular Formula:C₆₆H₁₀₅N₅O₁₇Si
Molecular Weight:1268.67
Hs Code.:

C<sub>66</sub>H<sub>105</sub>N<sub>5</sub>O<sub>17</sub>Si

Synonyms:

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Chemical Property of C₆₆H₁₀₅N₅O₁₇Si

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Technology Process of C₆₆H₁₀₅N₅O₁₇Si

There total 11 articles about C₆₆H₁₀₅N₅O₁₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 383910-61-0
C₆₆H₁₀₅N₅O₁₇Si

Guidance literature:: Multi-step reaction with 8 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

5.1: 63 percent / HATU; DIEA / CH₂Cl₂ / 14 h / 0 - 20 °C

6.1: 75 percent / aq. AcOH / tetrahydrofuran / 24 h / 20 °C

7.1: Dess-Martin periodinane / CH₂Cl₂

8.1: 0.504 g / NaOCl₂; aq. H₂PO₄*H₂O / dimethylsulfoxide; acetonitrile / 16 h

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; dihydrogen phosphate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile; 7.1: Dess-Martin oxidation;
DOI:10.1021/jo0105991

Reference yield:

: 383910-54-1
N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid

: 383910-61-0
C₆₆H₁₀₅N₅O₁₇Si

Guidance literature:: Multi-step reaction with 8 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

5.1: 63 percent / HATU; DIEA / CH₂Cl₂ / 14 h / 0 - 20 °C

6.1: 75 percent / aq. AcOH / tetrahydrofuran / 24 h / 20 °C

7.1: Dess-Martin periodinane / CH₂Cl₂

8.1: 0.504 g / NaOCl₂; aq. H₂PO₄*H₂O / dimethylsulfoxide; acetonitrile / 16 h

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; dihydrogen phosphate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile; 7.1: Dess-Martin oxidation;
DOI:10.1021/jo0105991

Reference yield:

: 383910-53-0
methyl N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylate

: 383910-61-0
C₆₆H₁₀₅N₅O₁₇Si

Guidance literature:: Multi-step reaction with 9 steps

1.1: 97 percent / LiOH*H₂O / tetrahydrofuran; methanol / 18 h / 0 - 20 °C

2.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

3.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

4.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

4.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

5.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

6.1: 63 percent / HATU; DIEA / CH₂Cl₂ / 14 h / 0 - 20 °C

7.1: 75 percent / aq. AcOH / tetrahydrofuran / 24 h / 20 °C

8.1: Dess-Martin periodinane / CH₂Cl₂

9.1: 0.504 g / NaOCl₂; aq. H₂PO₄*H₂O / dimethylsulfoxide; acetonitrile / 16 h

With 4-methyl-morpholine; dmap; lithium hydroxide; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; dihydrogen phosphate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile; 8.1: Dess-Martin oxidation;
DOI:10.1021/jo0105991