(S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester

Base Information

• Chemical Name: (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester
• CAS No.: 208051-31-4
• Molecular Formula: C₂₄H₂₆N₂O₈S
• Molecular Weight: 502.545

Synonyms:

Chemical Property of (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester

There total 3 articles about (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ6-thia-2-aza-anthracene-3-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid methyl ester (208051-33-6) → (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ6-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester (208051-31-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2003.11.037

Reference yield:

methyl 3(S)-amino-2(R,S)-hydroxy-4-phenylbutanoate hydrochloride → (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ6-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester (208051-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HOBt; BOP; NMM / dimethylformamide / 0 - 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.11.037

Reference yield:

3,4-dihydro-6,7-ethylenedioxy-2-ethyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide (208050-37-7) → (S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ6-thia-2-aza-anthracene-3-carbonyl)-amino]-2-oxo-4-phenyl-butyric acid methyl ester (208051-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HOBt; BOP; NMM / dimethylformamide / 0 - 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.11.037

upstream raw materials:

(S)-3-[(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-1λ⁶-thia-2-aza-anthracene-3-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid methyl ester

3,4-dihydro-6,7-ethylenedioxy-2-ethyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide

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