6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Base Information

Chemical Name:6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid
CAS No.:631911-30-3
Molecular Formula:C₄₂H₅₇N₇O₁₁S₃
Molecular Weight:932.153
Hs Code.:

6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

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Chemical Property of 6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

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Technology Process of 6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

There total 9 articles about 6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 631911-30-3
6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:

Reference yield:

: 631911-27-8
6-{3-[3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-4-(2-trimethylsilanyl-ethoxycarbonylamino)-biphenyl-2-yl]-ureido}-hexanoic acid ethyl ester

: 631911-30-3
6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 40 °C

3: methanol; acetic acid / 2 h / 40 °C

With methanol; tetrabutyl ammonium fluoride; acetic acid; lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.06.030

Reference yield:

: C₈H₅BrN₂O₃

: 631911-30-3
6-(3-{4-(N,N'-bis-tert-butoxycarbonyl)-guanidino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:: Multi-step reaction with 8 steps

2: iron; ammonium chloride / ethanol / 14 h / 85 °C

3: palladium diacetate; triethylamine / 1,4-dioxane / 1 h / 80 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 16 h / 80 °C

5: dichloromethane / 0.67 h

6: lithium hydroxide / tetrahydrofuran

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 40 °C

8: methanol; acetic acid / 2 h / 40 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; palladium diacetate; iron; sodium carbonate; ammonium chloride; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2012.06.030