Technology Process of C22H21ClO
There total 2 articles about C22H21ClO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; paraffin oil / 0.33 h / 0 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 48 h / 20 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sodium hydride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; paraffin oil;
DOI:10.1002/anie.201202125
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; paraffin oil / 0.33 h / 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 48 h / 20 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sodium hydride; triethylamine;
In
1-methyl-pyrrolidin-2-one; paraffin oil;
DOI:10.1002/anie.201202125
- Guidance literature:
-
With
(R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen;
In
1,2-dichloro-ethane;
at 80 ℃;
for 90h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201202125
