methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

Base Information

Chemical Name:methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside
CAS No.:221015-76-5
Molecular Formula:C₃₈H₅₂O₁₀Si
Molecular Weight:696.91
Hs Code.:

methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

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Suppliers and Price of methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

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Chemical Property of methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

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Technology Process of methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

There total 2 articles about methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127244-81-9
methyl 2,3-O-isopropylidene-α-D-mannofuranoside 5,6-O-cyclic sulfate

: 221015-76-5
methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / dimethylformamide; xylene / 0.58 h / -5 °C

2: 86 percent / imidazole / dimethylformamide / 12 h / 90 °C

3: 1.) BuLi, HMPA / 1.) THF, r.t., 1 h, 2.) THF, -5 deg C, overnight

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In N,N-dimethyl-formamide; xylene;
DOI:10.1055/s-1999-3389

Reference yield:

: 127244-81-9
methyl 2,3-O-isopropylidene-α-D-mannofuranoside 5,6-O-cyclic sulfate

: 221015-74-3
methyl 5-O-tert-butyldiphenylsilyl-6,7,8-trideoxy-2,3-O-isopropylidene-α-D-manno-oct-7-ynofuranoside

: 221015-76-5
methyl 6,7,8-trideoxy-2,3-O-isopropylidene-8-(methyl 5-O-tert-butyldiphenylsilyl-6-deoxy-2,3-O-isopropylidene-α-D-manno-furanosid-6-yl)-α-D-manno-oct-7-ynofuranoside

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; Yield given; Multistep reaction; 1.) THF, r.t., 1 h, 2.) THF, -5 deg C, overnight;
DOI:10.1055/s-1999-3389