C₂₁H₁₉FN₆OS

Base Information

Chemical Name:C₂₁H₁₉FN₆OS
CAS No.:1355249-68-1
Molecular Formula:C₂₁H₁₉FN₆OS
Molecular Weight:422.486
Hs Code.:

C<sub>21</sub>H<sub>19</sub>FN<sub>6</sub>OS

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₉FN₆OS

Chemical Property:

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Technology Process of C₂₁H₁₉FN₆OS

There total 9 articles about C₂₁H₁₉FN₆OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314140-29-8
2-(4-methoxybenzyl)-5,6,7,8-tetrahydro-2H-cycloheptapyrazol-4-one

: 1355249-68-1
C₂₁H₁₉FN₆OS

Guidance literature:: Multi-step reaction with 3 steps

1: phenyltrimethylammonium tribromide / chloroform / 0.5 h / Reflux

2: ethanol / 2 h / Reflux

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With phenyltrimethylammonium tribromide; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; chloroform;

Reference yield:

: 1355249-61-4
ethyl 3-bromo-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate

: 1355249-68-1
C₂₁H₁₉FN₆OS

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Reflux

2.1: sodium hydroxide / methanol / 2 h / Reflux

2.2: pH 2 - 3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: magnesium / tetrahydrofuran / 60 - 70 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 18 h / Inert atmosphere; Reflux

7.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C / 760.05 Torr

8.1: phenyltrimethylammonium tribromide / chloroform / 0.5 h / Reflux

9.1: ethanol / 2 h / Reflux

10.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With oxalyl dichloride; hydrogen; phenyltrimethylammonium tribromide; caesium carbonate; magnesium; triethylamine; sodium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; toluene;

Reference yield:

: 1314139-89-3
5-bromo-2-(4-methoxybenzyl)-5,6,7,8-tetrahydro-2H-cycloheptapyrazol-4-one

: 1355249-68-1
C₂₁H₁₉FN₆OS

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol;