C₂₈H₃₈ClN₅O₂*C₄H₄O₄

Base Information

Chemical Name:C₂₈H₃₈ClN₅O₂*C₄H₄O₄
CAS No.:1448902-72-4
Molecular Formula:C₄H₄O₄*C₂₈H₃₈ClN₅O₂
Molecular Weight:628.168
Hs Code.:

C<sub>28</sub>H<sub>38</sub>ClN<sub>5</sub>O<sub>2</sub>*C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>

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Chemical Property of C₂₈H₃₈ClN₅O₂*C₄H₄O₄

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Technology Process of C₂₈H₃₈ClN₅O₂*C₄H₄O₄

There total 14 articles about C₂₈H₃₈ClN₅O₂*C₄H₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4-dioxo-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester

: 1448902-72-4
C₂₈H₃₈ClN₅O₂*C₄H₄O₄

Guidance literature:: Multi-step reaction with 17 steps

1: C₂₈H₂₇F₆N₃O₃S / tetrahydrofuran / 24 h / -20 °C

2: diphenylphosphoranyl azide; triethylamine / toluene / 15 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 1 h / 20 °C

6: dichloromethane / 2 h / 20 °C

7: N-chloro-succinimide / dichloromethane / 2 h / 20 °C

8: 18 h / 60 °C

9: hydrogenchloride / dichloromethane; water / 4 h / 40 °C

10: thionyl chloride / 1 h / 20 °C

11: acetic acid / toluene / 2 h / 110 °C

12: sodium cyanoborohydride / 6 h / 20 °C

13: triethylamine / dichloromethane / 5 h / 0 - 40 °C

14: sodium hydroxide; water / methanol / 0.5 h / 50 °C

15: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

16: thiophenol; caesium carbonate / acetonitrile / 1.5 h / 20 °C

17: methanol / 0.02 h / 20 °C

With morpholine; hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; C₂₈H₂₇F₆N₃O₃S; diphenylphosphoranyl azide; water; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Curtius Rearrangement;
DOI:10.1016/j.bmcl.2012.09.103

Reference yield:

: C₁₁H₁₈N₂O₄

: 1448902-72-4
C₂₈H₃₈ClN₅O₂*C₄H₄O₄

Guidance literature:: Multi-step reaction with 14 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 1 h / 20 °C

3: dichloromethane / 2 h / 20 °C

4: N-chloro-succinimide / dichloromethane / 2 h / 20 °C

5: 18 h / 60 °C

6: hydrogenchloride / dichloromethane; water / 4 h / 40 °C

7: thionyl chloride / 1 h / 20 °C

8: acetic acid / toluene / 2 h / 110 °C

9: sodium cyanoborohydride / 6 h / 20 °C

10: triethylamine / dichloromethane / 5 h / 0 - 40 °C

11: sodium hydroxide; water / methanol / 0.5 h / 50 °C

12: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

13: thiophenol; caesium carbonate / acetonitrile / 1.5 h / 20 °C

14: methanol / 0.02 h / 20 °C

With morpholine; hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; water; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.09.103

Reference yield:

: 1415413-39-6
C₁₇H₂₁N₃O₈S

: 1448902-72-4
C₂₈H₃₈ClN₅O₂*C₄H₄O₄

Guidance literature:: Multi-step reaction with 13 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 1 h / 20 °C

2: dichloromethane / 2 h / 20 °C

3: N-chloro-succinimide / dichloromethane / 2 h / 20 °C

4: 18 h / 60 °C

5: hydrogenchloride / dichloromethane; water / 4 h / 40 °C

6: thionyl chloride / 1 h / 20 °C

7: acetic acid / toluene / 2 h / 110 °C

8: sodium cyanoborohydride / 6 h / 20 °C

9: triethylamine / dichloromethane / 5 h / 0 - 40 °C

10: sodium hydroxide; water / methanol / 0.5 h / 50 °C

11: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

12: thiophenol; caesium carbonate / acetonitrile / 1.5 h / 20 °C

13: methanol / 0.02 h / 20 °C

With morpholine; hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; water; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.09.103