(E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

Base Information

Chemical Name:(E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite
CAS No.:1440908-86-0
Molecular Formula:C₄₈H₅₅N₄O₉P
Molecular Weight:862.96
Hs Code.:

(E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

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Chemical Property of (E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

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Technology Process of (E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

There total 2 articles about (E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 1440908-86-0
(E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 19 h / 20 °C / Inert atmosphere

2: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / acetonitrile; water / 4 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

With pyridine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; triethylamine; In dichloromethane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jm301838y

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1440908-86-0
(E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(4-methoxystyryl) 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl cyanomethyldiisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 19 h / 20 °C / Inert atmosphere

2: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / acetonitrile; water / 4 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

With pyridine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; triethylamine; In dichloromethane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jm301838y