C₃₂H₂₈F₃NO₄

Base Information

• Chemical Name: C₃₂H₂₈F₃NO₄
• CAS No.: 1315308-16-7
• Molecular Formula: C₃₂H₂₈F₃NO₄
• Molecular Weight: 547.574
• Mol file: 1315308-16-7.mol

Synonyms:

Chemical Property of C₃₂H₂₈F₃NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₈F₃NO₄

There total 8 articles about C₃₂H₂₈F₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 7-(4-(trifluoromethyl)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate (1160270-14-3) → C32H28F3NO4 (1315308-16-7)

Guidance literature:

Multi-step reaction with 7 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; N,N-dimethyl-formamide / 85 °C

2: palladium on carbon; hydrogen / ethyl acetate

3: trifluoroacetic acid / dichloromethane

4: sodium carbonate / tetrahydrofuran; water

5: methanol; lithium hydroxide / tetrahydrofuran / 45 °C

6: potassium carbonate / N,N-dimethyl-formamide / 20 - 45 °C

With methanol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on carbon; hydrogen; sodium carbonate; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.113

Reference yield:

tert-butyl 4-(4-(3-(ethoxycarbonyl)-6-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)phenyl)-3,6-dihydropyridine-1(2H)-carboxylate → C32H28F3NO4 (1315308-16-7)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium on carbon; hydrogen / ethyl acetate

2: trifluoroacetic acid / dichloromethane

3: sodium carbonate / tetrahydrofuran; water

4: methanol; lithium hydroxide / tetrahydrofuran / 45 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 - 45 °C

With methanol; palladium on carbon; hydrogen; sodium carbonate; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.113

Reference yield:

ethyl 4-(4-(piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoate (1160271-32-8) → C32H28F3NO4 (1315308-16-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / tetrahydrofuran; water

2: methanol; lithium hydroxide / tetrahydrofuran / 45 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 45 °C

With methanol; sodium carbonate; potassium carbonate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.113

upstream raw materials:

ethyl 7-(4-(trifluoromethyl)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

ethyl 4-(4-(piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoate

tert-butyl 4-(4-(3-(ethoxycarbonyl)-6-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)phenyl)piperidine-1-carboxylate

C₃₇H₃₀F₃NO₄