1,3-Dioxane,2-(2-chlorophenyl)-(9CI)

Base Information

• Chemical Name: 1,3-Dioxane,2-(2-chlorophenyl)-(9CI)
• CAS No.: 5406-38-2
• Molecular Formula: C10H11 Cl O2
• Molecular Weight: 198.649
• Hs Code.: 2934999090
• Mol file: 5406-38-2.mol

Synonyms:m-Dioxane,2-(o-chlorophenyl)- (6CI,7CI,8CI); 2-(2-Chlorophenyl)-1,3-dioxane;2-(o-Chlorophenyl)-1,3-dioxane; NSC 6999

Chemical Property of 1,3-Dioxane,2-(2-chlorophenyl)-(9CI)

Chemical Property:

• Vapor Pressure: 0.00927mmHg at 25°C
• Boiling Point: 274°Cat760mmHg
• Flash Point: 106.1°C
• PSA: 18.46000
• Density: 1.206g/cm³
• LogP: 2.77550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxane,2-(2-chlorophenyl)-(9CI)

There total 3 articles about 1,3-Dioxane,2-(2-chlorophenyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chlorobenzaldehyde dimethyl acetal (70380-66-4) + trimethyleneglycol (504-63-2) → 2-(2-chlorophenyl)-1,3-dioxane (5406-38-2)

Guidance literature:

With povidone-iodine; In acetonitrile; at 60 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tet.2021.132250

Reference yield: 91.0%

2-chloro-benzaldehyde (89-98-5) + trimethyleneglycol (504-63-2) → 2-(2-chlorophenyl)-1,3-dioxane (5406-38-2)

Guidance literature:

With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; orthoformic acid triethyl ester; In ethanol; at 50 ℃; for 4h;

DOI:10.1246/bcsj.75.2195

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 2-(2-chlorophenyl)-1,3-dioxane (5406-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: povidone-iodine / 3 h / 30 °C / Green chemistry

2: povidone-iodine / acetonitrile / 3 h / 60 °C / Green chemistry

With povidone-iodine; In acetonitrile;

DOI:10.1016/j.tet.2021.132250

upstream raw materials:

2-chloro-benzaldehyde

trimethyleneglycol

2-chlorobenzaldehyde dimethyl acetal

Downstream raw materials:

2-(2-chlorophenyl)-1,3-dithiane

2-chloro-benzaldehyde