(6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS No.: 176518-99-3
• Molecular Formula: C₃₀H₂₈ClN₃O₇S₂
• Molecular Weight: 642.153

Synonyms:

Chemical Property of (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 1 articles about (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloroethyl isothiocyanate (1943-83-5) + 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester (29126-13-4) → (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (176518-99-3)

Guidance literature:

With pyridine; 3-chloro-benzenecarboperoxoic acid; isopropyl alcohol; Yield given. Multistep reaction; 1.) a) -23 deg C, 0.5 h, b) RT, 4 h, 2.) CHCl₃, 0 deg C;

DOI:10.1016/0040-4020(96)00228-1

Reference yield: 49.0%

(6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (176518-99-3) → (6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (176518-97-1)

Guidance literature:

With phosphorus trichloride; In dichloromethane; for 4h; Heating;

DOI:10.1016/0040-4020(96)00228-1

Reference yield:

(6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (176518-99-3) → diphenylmethyl 3-(2-chloroethyl-N-nitrosocarbamoyl)methyl-7β-(2-thienylacetamido)-3-cephem-4-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / PCl₃ / CH₂Cl₂ / 4 h / Heating

2: 87 percent / N₂O₄, sodium acetate / CH₂Cl₂ / 0.5 h / -78 - -23 °C

With sodium acetate; dinitrogen tetraoxide; phosphorus trichloride; In dichloromethane;

DOI:10.1016/0040-4020(96)00228-1

upstream raw materials:

2-chloroethyl isothiocyanate

3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

Downstream raw materials:

(6R,7R)-3-(2-Chloro-ethylcarbamoyloxymethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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