1-(4-methoxyphenyl)-ethanethiol

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-ethanethiol
• CAS No.: 1245715-73-4
• Molecular Formula: C₉H₁₂OS
• Molecular Weight: 168.26
• Mol file: 1245715-73-4.mol

Synonyms:

Chemical Property of 1-(4-methoxyphenyl)-ethanethiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-ethanethiol

There total 3 articles about 1-(4-methoxyphenyl)-ethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

1-(4-methoxyphenyl)ethane-1-thiol → 1-(4-methoxyphenyl)-ethanethiol (1245715-73-4) + 4-methoxythioacetophenone

Guidance literature:

With 1,4-dithio-D,L-threitol; 5-(hydroxymethyl)furfural oxidase Val₄₆₅Thr mutant; In aq. phosphate buffer; isopropyl alcohol; at 30 ℃; for 24h; pH=7; enantioselective reaction; Resolution of racemate;

DOI:10.1002/anie.201713189

Reference yield:

rac-1-(4-methoxyphenyl)-ethanol (3319-15-1) → 1-(4-methoxyphenyl)-ethanethiol (1245715-73-4) + 4-methoxythioacetophenone

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

3: 5-(hydroxymethyl)furfural oxidase Val₄₆₅Thr mutant; 1,4-dithio-D,L-threitol / aq. phosphate buffer; isopropyl alcohol / 24 h / 30 °C / pH 7 / Resolution of racemate

With lithium aluminium tetrahydride; 1,4-dithio-D,L-threitol; di-isopropyl azodicarboxylate; 5-(hydroxymethyl)furfural oxidase Val₄₆₅Thr mutant; triphenylphosphine; In tetrahydrofuran; aq. phosphate buffer; isopropyl alcohol; 1: |Mitsunobu Displacement;

DOI:10.1002/anie.201713189

Reference yield:

thioacetic acid [1-(4-methoxyphenyl)-ethyl] ester → 1-(4-methoxyphenyl)-ethanethiol (1245715-73-4) + 4-methoxythioacetophenone

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

2: 5-(hydroxymethyl)furfural oxidase Val₄₆₅Thr mutant; 1,4-dithio-D,L-threitol / aq. phosphate buffer; isopropyl alcohol / 24 h / 30 °C / pH 7 / Resolution of racemate

With lithium aluminium tetrahydride; 1,4-dithio-D,L-threitol; 5-(hydroxymethyl)furfural oxidase Val₄₆₅Thr mutant; In tetrahydrofuran; aq. phosphate buffer; isopropyl alcohol;

DOI:10.1002/anie.201713189

upstream raw materials:

rac-1-(4-methoxyphenyl)-ethanol